Pharmacogenomics in cardiovascular precision medicine
نویسندگان
چکیده
منابع مشابه
Applied pharmacogenomics in cardiovascular medicine.
Interindividual heterogeneity in drug response is a central feature of all drug therapies. Studies in individual patients, families, and populations over the past several decades have identified variants in genes encoding drug elimination or drug target pathways that in some cases contribute substantially to variable efficacy and toxicity. Important associations of pharmacogenomics in cardiovas...
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For precision medicine to become a reality, we propose 3 changes. First, healthcare deliverables must be prioritized, enabling translation of knowledge to the clinic. Second, physicians and patients must be convinced to participate, requiring additional infrastructure in health systems. Third, discovery science must evolve to shift the preclinical landscape for innovation. We propose a change i...
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BACKGROUND Precision medicine is becoming a major topic within the medical community and is gaining traction as a standard approach in many disciplines. This approach typically revolves around the use of a patient's genetic makeup to allow the physician to choose the appropriate course of treatment. In many cases the genetic information directs the drug to be used to treat the patient. In other...
متن کاملPharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine
Some of the most commonly prescribed medications are those for cardiovascular maladies. The beneficial effects of these medications have been well documented. However, there can be substantial variation in response to these medications among patients, which may be due to genetic variation. For this reason pharmacogenomic studies are emerging across all aspects of cardiovascular medicine. The go...
متن کاملPharmacogenomics of G protein-coupled receptor ligands in cardiovascular medicine.
Agonists and antagonists of G protein-coupled receptors are important drugs for the treatment of cardiovascular disease, but the therapeutic response of any given patient remains difficult to predict because of large interindividual variability. Among the factors potentially contributing to such variability, we have reviewed the evidence for a role of pharmacodynamic pharmacogenetics (i.e., pol...
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ژورنال
عنوان ژورنال: Journal of Laboratory and Precision Medicine
سال: 2020
ISSN: 2519-9005
DOI: 10.21037/jlpm-2019-cpm-05